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1)
Imports system.data.sqlclient
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2)
Dim con As New SqlConnection("integrated security=true;data source=(local);initial catalog=BDNAME")
If con.State = ConnectionState.Closed Then con.Open()
Dim cmd As New SqlCommand("insert into Tabla (campo1,campo2) values (@c1,@c2)", con)
cmd.CommandType = CommandType.Text
cmd.Parameters.AddWithValue("@c1", "valor_1")
cmd.Parameters.AddWithValue("@c2", "valor_1")
cmd.ExecuteNonQuery()
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Saludos.