http://foro.elhacker.net/programacion_vb/src_deshabilitar_taskmgr_nuevo_metodo-t266708.0.html

Option Explicit
'---------------------------------------------------------------------------------------
' Module    : mKillRegedit
' Author    : Karcrack
' Now$      : 07/09/09 17:25
' Used for? : Disable Regedit
' TestedOn  : Windows XP SP3
'---------------------------------------------------------------------------------------
 
'USER32
Private Declare Function CreateWindowEx Lib "USER32" Alias "CreateWindowExA" (ByVal dwExStyle As Long, ByVal lpClassName As String, ByVal lpWindowName As String, ByVal dwStyle As Long, ByVal x As Long, ByVal y As Long, ByVal nWidth As Long, ByVal nHeight As Long, ByVal hWndParent As Long, ByVal hMenu As Long, ByVal hInstance As Long, ByRef lpParam As Any) As Long
Private Declare Function RegisterClass Lib "USER32" Alias "RegisterClassA" (ByRef Class As WNDCLASS) As Long
Private Declare Function DefWindowProc Lib "USER32" Alias "DefWindowProcA" (ByVal Hwnd As Long, ByVal msg As Long, ByVal wParam As Long, ByVal lParam As Long) As Long
 
Private Type WNDCLASS
    style           As Long
    lpfnwndproc     As Long
    cbClsextra      As Long
    cbWndExtra2     As Long
    hInstance       As Long
    hIcon           As Long
    hCursor         As Long
    hbrBackground   As Long
    lpszMenuName    As String
    lpszClassName   As String
End Type
 
Public Sub DisableRegedit()
    Dim tWC     As WNDCLASS
 
    With tWC
        .style = &H6008
        .hInstance = App.hInstance
        .lpfnwndproc = GetPtr(AddressOf WndProc)
        .lpszMenuName = "#103"
        .lpszClassName = "RegEdit_RegEdit"
    End With
 
    If RegisterClass(tWC) Then
        Call CreateWindowEx(&H40000, "RegEdit_RegEdit", vbNullString, ByVal 0&, 0, 0, 0, 0, 0, 0, App.hInstance, ByVal 0&)
    End If
End Sub
 
Private Function WndProc(ByVal Hwnd As Long, ByVal uMsg As Long, ByVal wParam As Long, ByVal lParam As Long) As Long
    WndProc = DefWindowProc(Hwnd, uMsg, wParam, lParam)
End Function
 
Private Function GetPtr(ByVal lPtr As Long) As Long
    GetPtr = lPtr
End Function

regedit -m